{"id":2880,"date":"2022-01-20T11:35:33","date_gmt":"2022-01-20T10:35:33","guid":{"rendered":"https:\/\/poryatunok.info\/about-ph\/%d0%b4%d0%be%d1%81%d0%bb%d1%96%d0%b4%d0%b6%d0%b5%d0%bd%d0%bd%d1%8f\/"},"modified":"2022-02-15T13:40:04","modified_gmt":"2022-02-15T12:40:04","slug":"research","status":"publish","type":"page","link":"https:\/\/poryatunok.info\/en\/about-ph\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row row_space=&#8221;remove_padding&#8221;][vc_column][gva_block_heading title=&#8221;Research&#8221; align=&#8221;align-left&#8221;][\/gva_block_heading][vc_column_text]<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-1837\" src=\"https:\/\/www.phaeurope.org\/wp-content\/uploads\/research.jpg\" alt=\"Research\" width=\"550\" height=\"367\" \/>In the past 15-20 years enormous progress has been made in the treatment of pulmonary arterial hypertension, PAH, one of the five subtypes of pulmonary hypertension (<a title=\"Classification and WHO functional class\" href=\"https:\/\/www.phaeurope.org\/about-ph\/classification-and-who-functional-class\/\">WHO group 1<\/a>). The new treatments have led to significant improvements for patients in terms of symptoms, disease progression and survival.<br \/>\nIn 2013 a soluble guanylate cyclase stimulator was approved as the first treatment specifically for patients with chronic thromboembolic pulmonary hypertension, <a title=\"What is CTEPH?\" href=\"https:\/\/www.phaeurope.org\/about-ph\/what-is-cteph\/\">CTEPH<\/a> (<a title=\"Classification and WHO functional class\" href=\"https:\/\/www.phaeurope.org\/about-ph\/classification-and-who-functional-class\/\">WHO group 4<\/a>).<!--more--><br \/>\nCurrently there are no approved PH drugs for the other three classes of pulmonary hypertension (<a title=\"Classification and WHO functional class\" href=\"https:\/\/www.phaeurope.org\/about-ph\/classification-and-who-functional-class\/\">WHO groups 2, 3 and 5<\/a>). Research on new treatments in currently ongoing and may in the near future lead to new drug approvals.<\/p>\n<p style=\"text-align: justify;\">In the European Union the clinical trials directive ensured a certain level harmonization of clinical trials, including how clinical trials can be conducted and how to protect the patients\u2019 rights. The directive, however, will be replaced by the clinical trials regulation, which brings in:<\/p>\n<ul>\n<li>A streamlined application procedure via a single entry point &#8211; an EU portal and database, for all clinical trials conducted in Europe;<\/li>\n<li>A single authorisation procedure for all clinical trials, allowing a faster and thorough assessment;<\/li>\n<li>The extension of the tacit agreement principle to the whole authorisation process which will give sponsors and researchers, in particular SMEs and academics, more legal certainty;<\/li>\n<li>Strengthened transparency for clinical trials data.1<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">Hopefully the new set of rules will result in favorable changes for patients to enroll in clinical trials and further boost the research in PH.<\/p>\n<h3>Clinical trials registers:<\/h3>\n<p><strong>Europe:<\/strong><br \/>\n<a href=\"http:\/\/www.clinicaltrialsregister.eu\/\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/www.clinicaltrialsregister.eu\/<\/a><\/p>\n<p><strong>USA:<\/strong><br \/>\n<a href=\"http:\/\/clinicaltrials.gov\/\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/clinicaltrials.gov\/<\/a><\/p>\n<p><em>Reviewed by Prof. Simon J Gibbs<\/em><br \/>\nLast medical update: 05\/30\/2020<\/p>\n<h2>Sources<\/h2>\n<ol>\n<li><a href=\"https:\/\/ec.europa.eu\/health\/human-use\/clinical-trials\/information_en\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/ec.europa.eu\/health\/human-use\/clinical-trials\/information_en<\/a><\/li>\n<\/ol>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row row_space=&#8221;remove_padding&#8221;][vc_column][gva_block_heading title=&#8221;Research&#8221; align=&#8221;align-left&#8221;][\/gva_block_heading][vc_column_text] In the past 15-20 years enormous progress has been made in the treatment of pulmonary arterial hypertension, PAH, one of the five subtypes of pulmonary hypertension (WHO group 1). The new treatments have led to significant improvements for patients in terms of symptoms, disease progression and survival. In 2013 a soluble [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2814,"menu_order":460,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2880","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research - Sister Dalila<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phaeurope.org\/about-ph\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - Sister Dalila\" \/>\n<meta property=\"og:description\" content=\"[vc_row row_space=&#8221;remove_padding&#8221;][vc_column][gva_block_heading title=&#8221;Research&#8221; align=&#8221;align-left&#8221;][\/gva_block_heading][vc_column_text] In the past 15-20 years enormous progress has been made in the treatment of pulmonary arterial hypertension, PAH, one of the five subtypes of pulmonary hypertension (WHO group 1). The new treatments have led to significant improvements for patients in terms of symptoms, disease progression and survival. In 2013 a soluble [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.phaeurope.org\/about-ph\/research\/\" \/>\n<meta property=\"og:site_name\" content=\"Sister Dalila\" \/>\n<meta property=\"article:modified_time\" content=\"2022-02-15T12:40:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.phaeurope.org\/wp-content\/uploads\/research.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/poryatunok.info\\\/en\\\/about-ph\\\/research\\\/\",\"url\":\"https:\\\/\\\/www.phaeurope.org\\\/about-ph\\\/research\\\/\",\"name\":\"Research - Sister Dalila\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/poryatunok.info\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.phaeurope.org\\\/about-ph\\\/research\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.phaeurope.org\\\/about-ph\\\/research\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.phaeurope.org\\\/wp-content\\\/uploads\\\/research.jpg\",\"datePublished\":\"2022-01-20T10:35:33+00:00\",\"dateModified\":\"2022-02-15T12:40:04+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.phaeurope.org\\\/about-ph\\\/research\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.phaeurope.org\\\/about-ph\\\/research\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.phaeurope.org\\\/about-ph\\\/research\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.phaeurope.org\\\/wp-content\\\/uploads\\\/research.jpg\",\"contentUrl\":\"https:\\\/\\\/www.phaeurope.org\\\/wp-content\\\/uploads\\\/research.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.phaeurope.org\\\/about-ph\\\/research\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/poryatunok.info\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"About PH\",\"item\":\"https:\\\/\\\/poryatunok.info\\\/en\\\/about-ph\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Research\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/poryatunok.info\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/poryatunok.info\\\/en\\\/\",\"name\":\"Sister Dalila\",\"description\":\"Just another WordPress site\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/poryatunok.info\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Research - Sister Dalila","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.phaeurope.org\/about-ph\/research\/","og_locale":"en_US","og_type":"article","og_title":"Research - Sister Dalila","og_description":"[vc_row row_space=&#8221;remove_padding&#8221;][vc_column][gva_block_heading title=&#8221;Research&#8221; align=&#8221;align-left&#8221;][\/gva_block_heading][vc_column_text] In the past 15-20 years enormous progress has been made in the treatment of pulmonary arterial hypertension, PAH, one of the five subtypes of pulmonary hypertension (WHO group 1). The new treatments have led to significant improvements for patients in terms of symptoms, disease progression and survival. In 2013 a soluble [&hellip;]","og_url":"https:\/\/www.phaeurope.org\/about-ph\/research\/","og_site_name":"Sister Dalila","article_modified_time":"2022-02-15T12:40:04+00:00","og_image":[{"url":"https:\/\/www.phaeurope.org\/wp-content\/uploads\/research.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/poryatunok.info\/en\/about-ph\/research\/","url":"https:\/\/www.phaeurope.org\/about-ph\/research\/","name":"Research - Sister Dalila","isPartOf":{"@id":"https:\/\/poryatunok.info\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.phaeurope.org\/about-ph\/research\/#primaryimage"},"image":{"@id":"https:\/\/www.phaeurope.org\/about-ph\/research\/#primaryimage"},"thumbnailUrl":"https:\/\/www.phaeurope.org\/wp-content\/uploads\/research.jpg","datePublished":"2022-01-20T10:35:33+00:00","dateModified":"2022-02-15T12:40:04+00:00","breadcrumb":{"@id":"https:\/\/www.phaeurope.org\/about-ph\/research\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.phaeurope.org\/about-ph\/research\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.phaeurope.org\/about-ph\/research\/#primaryimage","url":"https:\/\/www.phaeurope.org\/wp-content\/uploads\/research.jpg","contentUrl":"https:\/\/www.phaeurope.org\/wp-content\/uploads\/research.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/www.phaeurope.org\/about-ph\/research\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/poryatunok.info\/en\/"},{"@type":"ListItem","position":2,"name":"About PH","item":"https:\/\/poryatunok.info\/en\/about-ph\/"},{"@type":"ListItem","position":3,"name":"Research"}]},{"@type":"WebSite","@id":"https:\/\/poryatunok.info\/en\/#website","url":"https:\/\/poryatunok.info\/en\/","name":"Sister Dalila","description":"Just another WordPress site","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/poryatunok.info\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/poryatunok.info\/en\/wp-json\/wp\/v2\/pages\/2880","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/poryatunok.info\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/poryatunok.info\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/poryatunok.info\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/poryatunok.info\/en\/wp-json\/wp\/v2\/comments?post=2880"}],"version-history":[{"count":4,"href":"https:\/\/poryatunok.info\/en\/wp-json\/wp\/v2\/pages\/2880\/revisions"}],"predecessor-version":[{"id":3274,"href":"https:\/\/poryatunok.info\/en\/wp-json\/wp\/v2\/pages\/2880\/revisions\/3274"}],"up":[{"embeddable":true,"href":"https:\/\/poryatunok.info\/en\/wp-json\/wp\/v2\/pages\/2814"}],"wp:attachment":[{"href":"https:\/\/poryatunok.info\/en\/wp-json\/wp\/v2\/media?parent=2880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}